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Beyond strategy: The secret ingredient of innovation

On the path to success, organizations define strategies, plan each step, and invest in crucial resources such as the sale of services and products, project applications, the development of solid business plans, and the protection of intellectual property. However, there is an often-neglected element that is fundamental to the flourishing of innovation: serendipity. But what exactly is this mysterious force, and why is it so vital to advancing agriculture and so many other areas?

When chance opens doors: The power of unplanned discovery

Serendipity lies in the art of finding something valuable when looking for something else. It's the unintentional discoveries that arise from unexpected situations. Throughout history, some of the most transformative innovations have not been the result of a rigorous plan, but rather of a fortuitous encounter with the unknown. Although deliberate research and methodical experimentation are pillars of scientific and technological progress, openness to the unexpected proves to be a powerful catalyst. When researchers cultivate this openness, they often come across revelations that have the potential to revolutionize entire industries, transform technologies, and expand our understanding of the world around us.

A close look at the “error”: The genesis of an innovative biofungicide

Today, we unveil the surprising and inspiring story of Maria Miguel, a talented researcher from the InPP's New Biopesticides Department, whose insight transformed a fortuitous event into a discovery of inestimable value: a broad-spectrum biofungicide capable of combating Botrytis cinerea, the relentless fungus responsible for the devastating gray mold disease in tomato plants. This pathology represents one of the greatest phytosanitary challenges in tomato cultivation, especially when grown in greenhouses, causing significant losses to producers if not controlled in a timely manner.

From discard to discovery: An investigator's insight

The journey of this discovery began in a scenario familiar to any researcher: the observation of Petri dishes, used to grow cell or microorganism cultures. In Maria Miguel's Petri dishes, colonies of the fungus Botrytis cinerea were growing, intentionally introduced there for study. However, something else caught her attention: one of the plates was contaminated by mold, and curiously, a clear zone surrounded this intruder. Instead of discarding the plate and ignoring it as mere contamination, Maria Miguel decided to investigate the reason behind that clear area. Her curiosity revealed that the mold had a surprising ability to inhibit the growth of Botrytis cinerea in its vicinity.

“Sometimes we look at something and think it's a mistake. The truth is that within a failure, there can be something good,” shares the researcher. The emotion and enthusiasm of a researcher when realizing that what at first seemed like an obstacle, a negative result, can actually be an opportunity, is contagious. For Maria Miguel, this “error” transformed into a serendipitous discovery with enormous potential.

Maria Miguel, a researcher at the InPP's Department of New Biopesticides, transformed an unexpected event into a groundbreaking discovery: a broad-spectrum biofungicide to combat gray mold in tomato plants.

Beyond chance: The active ingredients of scientific discovery

As the story of this biofungicide demonstrates, the world of science is full of examples of discoveries that arose from the unexpected. One of the most famous cases is the discovery of penicillin by Alexander Fleming in 1928. While observing Petri dishes, Fleming noticed that a mold was producing a substance that eliminated Staphylococcus aureus bacteria around it. He identified the mold as Penicillium notatum and named his revolutionary antibiotic penicillin. Penicillin ended up becoming an extremely important drug for fighting infections.

However, chance is not the only protagonist of these important revelations. “Sometimes we have to follow our intuition and be able to prove that we are right or wrong,” explains Maria Miguel. In addition to intuition, a generous dose of curiosity, an open mind to accept unexpected results, a solid scientific knowledge, and the ability to see and advance to further investigations on surprising results play a crucial role in the alchemy of discovery.

The ecosystem of discovery: Fostering an environment conducive to innovation

There are other ingredients that contribute to the recipe for scientific success:

  • Creativity: The ability to generate new perspectives, concepts, questions, or solutions, and the willingness to explore existing ideas under a new light.
  • Flexibility: The courage to venture into unknown territories without fear of failure, thus increasing the odds of serendipitous encounters.

But no discovery flourishes in isolation. At InPP, the strong team spirit and culture of collaboration transcend departmental boundaries. Maria Miguel's discovery is a testament to this synergy, as she herself acknowledges: “My colleagues opened doors so that I could do my research.”

To foster innovation, organizations need to cultivate an environment that stimulates open discussions and connects people from diverse areas of knowledge and life experiences, without judgment; that encourages curiosity and receptiveness to new experiences; and that promotes a relentless pursuit of improving scientific knowledge, the fertile ground where serendipity can germinate.

Sowing the future: The impact of a discovery and the path of research

Although Maria Miguel is about to embark on a new journey, driven by a prestigious Marie Skłodowska-Curie doctoral fellowship - a program that supports the career of researchers and promotes excellence and innovation in research - her legacy at InPP is already flourishing. Her innovative discovery is opening new and promising doors for future research in the area of crop protection, demonstrating how, at times, it is in the unexpected that the potential to transform our world lies.

Beyond strategy: The secret ingredient of innovation

On the road to success, organizations define strategies, plan every step and invest in crucial resources such as selling services and products, applying for projects, drawing up solid business plans and protecting intellectual property. However, there is an element that is often overlooked, but which is fundamental to the flourishing of innovation: serendipity. But what exactly is this mysterious force and why is it so vital to the advancement of agriculture and so many other areas?

When chance opens doors: The power of unplanned discovery

Serendipity is the art of finding something valuable when you're looking for something else. It's the unintentional discoveries that arise from unexpected situations. Throughout history, some of the most transformative innovations have not been the result of a rigorous plan, but rather a chance encounter with the unknown. While deliberate research and methodical experimentation are pillars of scientific and technological progress, openness to the unexpected proves to be a powerful catalyst. When researchers cultivate this openness, they often stumble upon revelations that have the potential to revolutionize entire industries, transform technologies and expand our understanding of the world around us.

A close look at “error”: The genesis of an innovative biofungicide

Today, we unveil the surprising and inspiring story of Maria Miguel, a talented researcher from InPP's New Biopesticides Department, whose acumen turned a chance event into a priceless discovery: a broad-spectrum biofungicide capable of combating the Botrytis cinerea, the relentless fungus responsible for the devastating gray rot disease in tomato plants. This pathology represents one of the biggest phytosanitary challenges in tomato cultivation, especially when grown in greenhouses, causing significant losses to producers if it is not controlled in good time.

From discard to discovery: The insight of a researcher

The journey of this discovery began in a setting familiar to any researcher: the observation of Petri dishes, used to grow cultures of cells or microorganisms. On Maria Miguel's plates, colonies of the fungus Botrytis cinerea were growing, intentionally introduced there for study. However, something else caught her eye: one of the plates was contaminated by mold, and curiously, a clear area surrounded this intruder. Instead of discarding the plate and dismissing it as mere contamination, Maria Miguel decided to investigate the reason behind the clear area. Her curiosity revealed that the mold had a surprising ability to prevent the growth of Botrytis cinerea in its vicinity.

“Sometimes we look at something and think it's a mistake. The truth is that in a failure there can be something good,” the researcher shares. The excitement and enthusiasm of a researcher realizing that what at first glance seemed like an obstacle, a negative result, could actually be an opportunity, is contagious. For Maria Miguel, this “mistake” turned into a serendipitous discovery with enormous potential.

Maria Miguel, a researcher at InPP's New Biopesticides Department, who turned an unexpected event into a discovery that changed the course of her work: a broad-spectrum biofungicide to combat gray rot in tomato plants.

Beyond chance: The active ingredients of scientific discovery

As the history of this biofungicide shows, the world of science is full of examples of discoveries that came out of the blue. One of the most famous cases is Alexander Fleming's discovery of penicillin in 1928. While observing Petri dishes, Fleming noticed that a mold was producing a substance that eliminated bacteria Staphylococcus aureus around him. He identified the mold as Penicillium notatum and named his revolutionary antibiotic penicillin. Penicillin ended up becoming an extremely important medicine for fighting infections.

However, chance is not the only protagonist of these important revelations. “Sometimes we have to follow our intuition and be able to prove ourselves right or wrong,” explains Maria Miguel. In addition to intuition, a generous dose of curiosity, an open mind to accept unexpected results, solid scientific knowledge and the ability to see and move on to further research into surprising results play a crucial role in the alchemy of discovery.

The discovery ecosystem: Fostering an environment conducive to innovation

There are other ingredients that contribute to the recipe for scientific success:

  • Creativity: The ability to generate new perspectives, concepts, questions or solutions, and the willingness to explore existing ideas in a new light.
  • Flexibility: The courage to venture into unknown territory without the fear of failure, thus increasing the chances of serendipitous encounters.

But no discovery flourishes in isolation. At InPP, the strong team spirit and culture of collaboration transcend departmental boundaries. The case of Maria Miguel's discovery is testimony to this synergy, as she herself acknowledges: “My colleagues opened doors so that I could do my research”.

To foster innovation, organizations need to cultivate an environment that encourages open discussions and connects people from different areas of knowledge and life experiences, without judgment; that encourages curiosity and receptiveness to new experiences; and that promotes an incessant quest to improve scientific knowledge, the fertile ground where serendipity can germinate.

Sowing the future: The impact of a discovery and the path of research

Although Maria Miguel is about to embark on a new journey, boosted by a prestigious Marie Skłodowska-Curie PhD scholarship - a program that supports the careers of researchers and promotes excellence and innovation in research - her legacy at InPP is already flourishing. Her groundbreaking discovery is opening promising new doors for future research in the field of crop protection, demonstrating how sometimes it is in the unexpected that the potential to transform our world lies.

In the March issue of Fruits, vegetables and flowers you will find the opinion article entitled “The role of InnovPlantProtect in Organic Farming: Paths to sustainable and efficient solutions”, in which the executive director of InnovPlantProtect (InPP), António Saraiva, reveals how our CoLAB is contributing to the success of organic farming.

“By boosting research, collaboration and knowledge sharing, InPP is helping to solve the central challenges of this practice [organic farming], allowing it to expand and enhancing the supply of agricultural products to consumers. The solutions developed by InPP make organic farming a more viable option for producers,” says the executive director.

Read the full article and find out how we are shaping the future of agriculture.

We thank Frutas, legumes e flores magazine for its recognition and reiterate our commitment to the agriculture of the future.

EVENTS

Last Friday, August 26, the InPP received a visit from Catalonia's Councillor for External Action and Open Government, Victòria Alsina, and the delegate of the Government of Catalonia in Portugal, Rui Reis, They were accompanied by the Councillor of Elvas City Council, Paula Calado.

They were received by the heads of department, David Learmonth, iLaria Marengo e Sandra Correia, They presented InPP's infrastructures, laboratories and the different areas of research being explored by the collaborative laboratory's five departments.

The aim of this visit was to create and establish new partnerships and collaborations with this autonomous community of Spain, a key international player for Portugal in its economic and scientific spheres, in which the agri-food industries play a major role. Establishing partnerships is part of InPP's philosophy and, therefore, this visit allowed us to explore the strengths of each of those involved and find points of synergy, where we wanted to identify areas of interest for possible partnerships and collaborations.

During the visit to InPP's facilities, the delegation also had the opportunity to speak to some of InPP's researchers, who were able to personally explain some of the research they are currently carrying out at InPP in the fight against emerging plant pests and diseases.

InnovPlantProtect (InPP) team identifies the most promising materials for encapsulating biological protection agents to control emerging pests and diseases in agricultural crops. Natural products of animal origin, from marine and terrestrial sources, as well as synthetic ones, have been the most widely used due to their low toxicity and biodegradability, the researchers conclude in a systematic review article now published in the scientific journal ACS Agricultural Science & Technology. But are these solutions scalable and economically viable?

Biological protection agents, microorganisms such as bacteria, fungi or biomolecules with active substances capable of preventing or controlling or suppressing pests and diseases in plants, have been considered more sustainable alternatives to traditional chemical pesticides. However, these agents are very sensitive to atmospheric conditions and begin to degrade due to humidity, temperature and solar radiation.

Due to the sensitivity of the active substances, the challenge is to develop a biodegradable and sustainable material that envelops, i.e. encapsulates the biological agents, protecting them so that they can be applied effectively to Mediterranean agricultural crops. The encapsulation of biological agents brings several advantages for the agricultural producer, namely ease of handling, controlled application of lower and less frequent dosages, greater specificity for the target, prolonged stability and maximized permanence, which leads to greater effectiveness of the biological agent in combating pests and diseases.

Schematic representation of the encapsulation process of a biological agent to protect pear pests

The team, from Formulations and Process Development Department of the InPP, reviewed 98 scientific articles, published between 2013 and 2022, and concluded that “micro and nanoencapsulation of biological protection agents using materials from marine, terrestrial or synthetic sources should provide agricultural producers with access to safer and more sustainable plant protection products”. The review article [1], entitled Micro- and Nanocarriers for Encapsulation of Biological Plant Protection Agents: A Systematic Literature Review, has just been published in the scientific journal ACS Agricultural Science & Technology.

The four researchers analyzed the studies with a view to “identifying the materials most commonly used to encapsulate biological agents for pest and disease control with greater efficacy, greater systemic activity and less environmental impact”. The researchers also analyzed the encapsulation methods and techniques currently being used by research teams in various parts of the world.

“The data presented in this article indicate that materials based on polymers, of natural or synthetic origin, and inorganic materials can improve the stability and performance of a wide range of bioinspired active substances,” say the researchers.

However, the team warns that “although research interest in these encapsulating materials is increasing, the current level of knowledge does not yet allow for a totally fair and unbiased assessment of the pros and cons that will arise from the use of micro and nano systems for encapsulating biological agents and their use in agriculture”, adding that “a better understanding of the fate and long-term safety of these products is needed”.

“Although the technologies presented in this review exhibit promising efficacy and safety profiles, it is unlikely that all of them will be scalable and transformable into economically viable solutions to current and future agricultural problems. More research and development of efforts against crop pests and diseases is needed, focusing on strategies that truly take into account the needs of farmers in agricultural fields, as only then will innovation be possible,” the team concludes.

Researchers Cláudia Silva, Tânia Pinto, Sónia Siquenique and David Learmonth

Original article

ACS Agricultural Science & Technology Journal

Micro- and Nanocarriers for Encapsulation of Biological Plant Protection Agents: A Systematic Literature Review

Tânia Pinto, Cláudia Silva, Sónia Siquenique and David Learmonth

DOI: https://doi.org/10.1021/acsagscitech.2c00113

[1] In a review article, researchers critically summarize what has already been studied and published by other scientists.

On August 18th, researchers from the New Biopesticides Department of InnovPlantProtect (InPP).., Pedro Rosa e Tiago Amaro, were in the Tagus/Sorraia basin, in Coruche and Porto Alto, in Samora Correia, to collect samples of rice infected with the fungus Magnaporthe oryzae, which causes pyriculariosis. The sampling was carried out as part of the BlaSTOP project - Developing integrated solutions to combat rice pyriculariosis.

As early as August 1st, the team had been to the Mondego basin, in Montemor-o-Velho, to take samples.

The BlaSTOP project aims to develop a sustainable and effective solution for controlling rice pyriculariosis caused by this fungus. The project has the support of COTArroz - Operational and Technological Center for Rice and Casa do Arroz, in the Tagus basin, and the Aparroz - Agrupamento de Produtores de Arroz do Vale do Sado Lda, in the Sado basin, where the team hopes to collect in the near future.

Sampling in the Tagus area, in Coruche and Porto Alto