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Beyond strategy: The secret ingredient of innovation

On the path to success, organizations define strategies, plan each step, and invest in crucial resources such as the sale of services and products, project applications, the development of solid business plans, and the protection of intellectual property. However, there is an often-neglected element that is fundamental to the flourishing of innovation: serendipity. But what exactly is this mysterious force, and why is it so vital to advancing agriculture and so many other areas?

When chance opens doors: The power of unplanned discovery

Serendipity lies in the art of finding something valuable when looking for something else. It's the unintentional discoveries that arise from unexpected situations. Throughout history, some of the most transformative innovations have not been the result of a rigorous plan, but rather of a fortuitous encounter with the unknown. Although deliberate research and methodical experimentation are pillars of scientific and technological progress, openness to the unexpected proves to be a powerful catalyst. When researchers cultivate this openness, they often come across revelations that have the potential to revolutionize entire industries, transform technologies, and expand our understanding of the world around us.

A close look at the “error”: The genesis of an innovative biofungicide

Today, we unveil the surprising and inspiring story of Maria Miguel, a talented researcher from the InPP's New Biopesticides Department, whose insight transformed a fortuitous event into a discovery of inestimable value: a broad-spectrum biofungicide capable of combating Botrytis cinerea, the relentless fungus responsible for the devastating gray mold disease in tomato plants. This pathology represents one of the greatest phytosanitary challenges in tomato cultivation, especially when grown in greenhouses, causing significant losses to producers if not controlled in a timely manner.

From discard to discovery: An investigator's insight

The journey of this discovery began in a scenario familiar to any researcher: the observation of Petri dishes, used to grow cell or microorganism cultures. In Maria Miguel's Petri dishes, colonies of the fungus Botrytis cinerea were growing, intentionally introduced there for study. However, something else caught her attention: one of the plates was contaminated by mold, and curiously, a clear zone surrounded this intruder. Instead of discarding the plate and ignoring it as mere contamination, Maria Miguel decided to investigate the reason behind that clear area. Her curiosity revealed that the mold had a surprising ability to inhibit the growth of Botrytis cinerea in its vicinity.

“Sometimes we look at something and think it's a mistake. The truth is that within a failure, there can be something good,” shares the researcher. The emotion and enthusiasm of a researcher when realizing that what at first seemed like an obstacle, a negative result, can actually be an opportunity, is contagious. For Maria Miguel, this “error” transformed into a serendipitous discovery with enormous potential.

Maria Miguel, a researcher at the InPP's Department of New Biopesticides, transformed an unexpected event into a groundbreaking discovery: a broad-spectrum biofungicide to combat gray mold in tomato plants.

Beyond chance: The active ingredients of scientific discovery

As the story of this biofungicide demonstrates, the world of science is full of examples of discoveries that arose from the unexpected. One of the most famous cases is the discovery of penicillin by Alexander Fleming in 1928. While observing Petri dishes, Fleming noticed that a mold was producing a substance that eliminated Staphylococcus aureus bacteria around it. He identified the mold as Penicillium notatum and named his revolutionary antibiotic penicillin. Penicillin ended up becoming an extremely important drug for fighting infections.

However, chance is not the only protagonist of these important revelations. “Sometimes we have to follow our intuition and be able to prove that we are right or wrong,” explains Maria Miguel. In addition to intuition, a generous dose of curiosity, an open mind to accept unexpected results, a solid scientific knowledge, and the ability to see and advance to further investigations on surprising results play a crucial role in the alchemy of discovery.

The ecosystem of discovery: Fostering an environment conducive to innovation

There are other ingredients that contribute to the recipe for scientific success:

  • Creativity: The ability to generate new perspectives, concepts, questions, or solutions, and the willingness to explore existing ideas under a new light.
  • Flexibility: The courage to venture into unknown territories without fear of failure, thus increasing the odds of serendipitous encounters.

But no discovery flourishes in isolation. At InPP, the strong team spirit and culture of collaboration transcend departmental boundaries. Maria Miguel's discovery is a testament to this synergy, as she herself acknowledges: “My colleagues opened doors so that I could do my research.”

To foster innovation, organizations need to cultivate an environment that stimulates open discussions and connects people from diverse areas of knowledge and life experiences, without judgment; that encourages curiosity and receptiveness to new experiences; and that promotes a relentless pursuit of improving scientific knowledge, the fertile ground where serendipity can germinate.

Sowing the future: The impact of a discovery and the path of research

Although Maria Miguel is about to embark on a new journey, driven by a prestigious Marie Skłodowska-Curie doctoral fellowship - a program that supports the career of researchers and promotes excellence and innovation in research - her legacy at InPP is already flourishing. Her innovative discovery is opening new and promising doors for future research in the area of crop protection, demonstrating how, at times, it is in the unexpected that the potential to transform our world lies.

Beyond strategy: The secret ingredient of innovation

On the road to success, organizations define strategies, plan every step and invest in crucial resources such as selling services and products, applying for projects, drawing up solid business plans and protecting intellectual property. However, there is an element that is often overlooked, but which is fundamental to the flourishing of innovation: serendipity. But what exactly is this mysterious force and why is it so vital to the advancement of agriculture and so many other areas?

When chance opens doors: The power of unplanned discovery

Serendipity is the art of finding something valuable when you're looking for something else. It's the unintentional discoveries that arise from unexpected situations. Throughout history, some of the most transformative innovations have not been the result of a rigorous plan, but rather a chance encounter with the unknown. While deliberate research and methodical experimentation are pillars of scientific and technological progress, openness to the unexpected proves to be a powerful catalyst. When researchers cultivate this openness, they often stumble upon revelations that have the potential to revolutionize entire industries, transform technologies and expand our understanding of the world around us.

A close look at “error”: The genesis of an innovative biofungicide

Today, we unveil the surprising and inspiring story of Maria Miguel, a talented researcher from InPP's New Biopesticides Department, whose acumen turned a chance event into a priceless discovery: a broad-spectrum biofungicide capable of combating the Botrytis cinerea, the relentless fungus responsible for the devastating gray rot disease in tomato plants. This pathology represents one of the biggest phytosanitary challenges in tomato cultivation, especially when grown in greenhouses, causing significant losses to producers if it is not controlled in good time.

From discard to discovery: The insight of a researcher

The journey of this discovery began in a setting familiar to any researcher: the observation of Petri dishes, used to grow cultures of cells or microorganisms. On Maria Miguel's plates, colonies of the fungus Botrytis cinerea were growing, intentionally introduced there for study. However, something else caught her eye: one of the plates was contaminated by mold, and curiously, a clear area surrounded this intruder. Instead of discarding the plate and dismissing it as mere contamination, Maria Miguel decided to investigate the reason behind the clear area. Her curiosity revealed that the mold had a surprising ability to prevent the growth of Botrytis cinerea in its vicinity.

“Sometimes we look at something and think it's a mistake. The truth is that in a failure there can be something good,” the researcher shares. The excitement and enthusiasm of a researcher realizing that what at first glance seemed like an obstacle, a negative result, could actually be an opportunity, is contagious. For Maria Miguel, this “mistake” turned into a serendipitous discovery with enormous potential.

Maria Miguel, a researcher at InPP's New Biopesticides Department, who turned an unexpected event into a discovery that changed the course of her work: a broad-spectrum biofungicide to combat gray rot in tomato plants.

Beyond chance: The active ingredients of scientific discovery

As the history of this biofungicide shows, the world of science is full of examples of discoveries that came out of the blue. One of the most famous cases is Alexander Fleming's discovery of penicillin in 1928. While observing Petri dishes, Fleming noticed that a mold was producing a substance that eliminated bacteria Staphylococcus aureus around him. He identified the mold as Penicillium notatum and named his revolutionary antibiotic penicillin. Penicillin ended up becoming an extremely important medicine for fighting infections.

However, chance is not the only protagonist of these important revelations. “Sometimes we have to follow our intuition and be able to prove ourselves right or wrong,” explains Maria Miguel. In addition to intuition, a generous dose of curiosity, an open mind to accept unexpected results, solid scientific knowledge and the ability to see and move on to further research into surprising results play a crucial role in the alchemy of discovery.

The discovery ecosystem: Fostering an environment conducive to innovation

There are other ingredients that contribute to the recipe for scientific success:

  • Creativity: The ability to generate new perspectives, concepts, questions or solutions, and the willingness to explore existing ideas in a new light.
  • Flexibility: The courage to venture into unknown territory without the fear of failure, thus increasing the chances of serendipitous encounters.

But no discovery flourishes in isolation. At InPP, the strong team spirit and culture of collaboration transcend departmental boundaries. The case of Maria Miguel's discovery is testimony to this synergy, as she herself acknowledges: “My colleagues opened doors so that I could do my research”.

To foster innovation, organizations need to cultivate an environment that encourages open discussions and connects people from different areas of knowledge and life experiences, without judgment; that encourages curiosity and receptiveness to new experiences; and that promotes an incessant quest to improve scientific knowledge, the fertile ground where serendipity can germinate.

Sowing the future: The impact of a discovery and the path of research

Although Maria Miguel is about to embark on a new journey, boosted by a prestigious Marie Skłodowska-Curie PhD scholarship - a program that supports the careers of researchers and promotes excellence and innovation in research - her legacy at InPP is already flourishing. Her groundbreaking discovery is opening promising new doors for future research in the field of crop protection, demonstrating how sometimes it is in the unexpected that the potential to transform our world lies.

In the March issue of Fruits, vegetables and flowers you will find the opinion article entitled “The role of InnovPlantProtect in Organic Farming: Paths to sustainable and efficient solutions”, in which the executive director of InnovPlantProtect (InPP), António Saraiva, reveals how our CoLAB is contributing to the success of organic farming.

“By boosting research, collaboration and knowledge sharing, InPP is helping to solve the central challenges of this practice [organic farming], allowing it to expand and enhancing the supply of agricultural products to consumers. The solutions developed by InPP make organic farming a more viable option for producers,” says the executive director.

Read the full article and find out how we are shaping the future of agriculture.

We thank Frutas, legumes e flores magazine for its recognition and reiterate our commitment to the agriculture of the future.

EVENTS

InnovPlantProtect (InPP) already has a camera walk-in with temperature control, humidity and exposure to light with photoperiod, to grow plants as part of their projects.

The Department for the Protection of Specific Crops has been using this new equipment since May 10, namely to grow Persian clover and wheat, for the PitSTOP projects, with Fertiprado, and WhYRust, respectively.

The climate chamber walk-in will allow experiments to be carried out under controlled conditions on different crops throughout the year. “Together with the renovation of the greenhouse, this plant growth environment is very important for expanding our response capacity,” explains Paula Oblessuc, director of that department.

“The climate chamber walk-in allows experiments to be carried out under controlled conditions all year round.

In other words, InPP researchers will be able to carry out more detailed experiments and work on a greater number of projects simultaneously, with a camera that “is maintaining the established conditions very well”, stresses Paula Oblessuc. The PitSTOP project aims to identify the pathogen(s) that is/are attacking Fertiprado's clover meadows and propose a solution to combat the disease(s).

WhYRust aims to combat wheat yellow rust, in particular by identifying resistance genes in the cereal, validating a warning system and developing genomic prediction models to support precision breeding.

The Rector of NOVA University Lisbon doesn't know if the special affection he feels for farmers comes from his “Alentejo rib” and his childhood connected to the land, but he does know that farmers play a crucial role in building a more sustainable world. So it is with enthusiasm that João Sàágua speaks of InnovPlantProtect, a collaborative laboratory led by NOVA, as an ally of sustainability in agricultural production, created to develop innovative solutions to protect crops from pests and diseases.

Watch the video on our YouTube

Text: Margarida Paredes/ InPP
Photos and video: NOVA University Lisbon


NOVA University Lisbon (NOVA) is the institution that has put the most effort into creating the InnovPlantProtect (InPP) Collaborative Laboratory (CoLab). Why is this project so important to NOVA?
Essentially for two reasons. Despite having excellent teaching and research, NOVA University still has a lot of room for growth in terms of knowledge transfer or, if you like, connection to society. In fact, one of the strong points of my candidacy for Rector of NOVA was the desire to increase the University's connection to society, in a visible and concrete way, and InnovPlantProtect is an example of this.

The other reason has to do with the topic itself: agriculture. The sustainability of agriculture and the guarantee of that sustainability based on knowledge and technology are fundamental to the country's development, in particular, but also to achieving the very important SDGs - Sustainable Development Goals. Let's just say that InPP represents NOVA's commitment to sustainable agriculture. I should also add that the enthusiasm with which the mayor of Elvas, Nuno Mocinha, welcomed us and supported the project from the outset has increased our desire to carry out this project and to do it in Elvas.

Is this CoLab “the apple of your eye”? I ask because NOVA, despite having eleven Collaborative Laboratories, has only led two projects, including this one.
It's true, we lead two CoLabs - this one and another in the health area - and we participate in nine others, but InPP really has all the conditions to be the “apple of my eye”. Firstly, because of its area of activity. Contributing to making the Mediterranean diet sustainable is very important to us, because we know that in doing so we are also supporting the country's development. Secondly, as the son of a woman from Alentejo, I consider this project's contribution to territorial cohesion to be crucial.

The InPP was approved by the FCT - Foundation for Science and Technology with the highest grade, after evaluation by an international team, and its work is already underway. What is NOVA's role in this project at the moment?
Our presence at InPP is permanent. It's visible in the Board of Directors, chaired by NOVA, and in the Management - the CEO, Professor Pedro Fevereiro, came from ITQB NOVA, a University Institute. In addition, in terms of research, we have joint projects that have already been submitted for funding. Another important aspect is the dual affiliation, which allows researchers from this University to also work at the CoLab for five years.

“I think the most important impact of the InPP will be the creation of economic and social value.”


As an entity that trains researchers, and given that this project was led by the GREEN-IT research unit of NOVA's Institute of Chemical and Biological Technology, in cooperation with other NOVA research units (CTS FCT NOVA, NOVA LINCS, FCT NOVA and MagiC NOVA IMS), is there any link between NOVA and InPP in terms of hiring highly qualified human resources?
There is strategic collaboration and exchange between researchers on both sides and also intense collaboration between several NOVA professors, from the various research centers you mentioned, at the InPP. But the InPP is hiring its own body of researchers, solid and with a high international profile, who will certainly also work on projects involving NOVA professors and researchers. I want to emphasize that I consider this aspect: progressively, the Elvas community is growing with people who work at the InPP and who make their living and have their family in Elvas.

“Given the particular nature of this CoLab, our expectation is that funding will come from its ability to innovate and even export innovation.”


What are the challenges facing a CoLab like InPP, the only one in this area in Portugal?
I would point to three fundamental challenges, the first of which is financial sustainability. CoLab has significant funding from the FCT - Foundation for Science and Technology, strong support from the Elvas local authority, which was crucial in launching this laboratory, and significant support from its various associates. But it will have to generate enough wealth in five years to guarantee its own financial sustainability.

Given the particular nature of this CoLab, our expectation is that funding will come from its ability to innovate and even export innovation. If InPP manages to develop products (such as biopesticides and plants resistant to pests and diseases) and services (such as forecasting and monitoring pests and diseases, among others) of sufficient quality and importance, it can not only guarantee its sustainability through the sale of these products and services, but also increase Portugal's export capacity in the area of knowledge in sustainable agriculture.

Another challenge, which I think has already been met, is attracting highly qualified human resources. As Elvas is not a major metropolis, it might have been difficult to attract an international scientific community and their families to the city, but it turned out not to be.

“In fact, InPP has all the conditions to be the ‘apple of my eye’.”.

In terms of fundamental knowledge, a lot of science has been funded and a lot of progress has been made in molecular-based technologies and tools, but the application is still residual. Do you believe that the InPP will reduce this gap?
I think so. One of the ways of reducing this gap is precisely related to one of the great challenges of Collaborative Laboratories, which is to increase export activity and the sale of products and services. The government has launched this initiative at a good time, and it's only fair to point this out.

I think the InPP has made a good start in this respect, having two multinational companies as founding members - Bayer and Syngenta - for whom this project is not merely commercial, but involves resources and knowledge. For this reason, their integration into this project had to be authorized by their parent companies in Germany, which shows the great commitment of these multinationals to InPP. In addition, we also have an impressive group of farmers from the region, who are the real lifeblood of the area, and who are represented on InPP's Governing Bodies through their associations.

InPP works on the protection of Mediterranean crops, but multinational companies invest more in corn, rapeseed, cotton and soy, because these are the crops that sell the most in the world. Aren't you worried about a lack of investment from companies?
Honestly, no. Mediterranean crops are an increasingly valued niche, first and foremost olive oil, for which demand is increasing significantly, but also fruit, vegetables and cereals. The Mediterranean diet has established itself as a healthy diet, and has taken on a leading role thanks to the widespread concern of the population about food, the problems of obesity and malnutrition, which is very much the result of the knowledge of the link between food, health and well-being. I have no doubt that the products of the Mediterranean diet will be booming in Europe, the United States and other territories. Again: a good export opportunity.

“Mediterranean crops are an increasingly valued niche, first and foremost olive oil, for which demand is increasing significantly, but also fruit, vegetables and cereals.”


Current EU legislation does not favor the use of New Genomic Techniques in Mediterranean crops. If the EU is not prepared to accept innovative solutions such as those that InPP is trying to develop, for example plants resistant to pests and diseases, what will be the alternative?
This is one of InPP's lines of activity, but not the only one. The European Union has yet to take a definitive stance on the matter, but if the plant breeding part of the project faces the difficulties you mentioned, the alternative is to sell the products in many other possible markets outside the EU. Furthermore, genomic techniques are not all the same, nor do they all respond to the same motivations; in the case of the InPP, sustainability and respect for the environment are also the motto here. In any case, as I said, we have other lines of activity, “all our eggs are not in one basket”.

What do you think will be the most important impact of the InPP?
I think it will be the creation of economic and social value. InnovPlantProtect will have a very important impact on Elvas, because by building a new community of national and foreign researchers it will contribute to territorial cohesion and development and to the socio-economic fabric of the city - I've heard that it's already difficult to find vacant housing.

The second impact will be visible in agricultural activity, as the InPP will develop products and services for crop protection, and the third will be on exports, as these products and services will also be made available on foreign markets.

“Given the particular nature of this CoLab, our expectation is that funding will come from its ability to innovate and even export innovation.”

JOÃO SÁGUA

Rector of NOVA University Lisbon (NOVA) since September 2017, he previously held the position of Vice-Rector of NOVA for Academic Affairs and International Relations (between 2014 and 2017). He holds a PhD in Contemporary Philosophy and is a Full Professor at NOVA's Faculty of Social Sciences and Humanities (FCSH/NOVA). He has been teaching at NOVA since 1980, accumulating a long experience as a teacher at all levels of education: bachelor's, master's and doctorate, in Portugal and abroad. In addition to an intensive teaching and research activity, he has held various management positions, namely at FCSH/NOVA, where he was Director (between 2005 and 2013) and Chairman of the Scientific Council (between 2009 and 2013).

Interview published first hand by Rural Life, March 2021 edition.

“I feel much more comfortable discussing these issues today in Portugal than I did ten years ago,” said the executive director of InnovPlantProtect (InPP) today, May 26. The question on the table was: “Are the new genomic techniques (NTG) one of the tools to achieve the goals of the Farm to Fork Strategy?”. For Pedro Fevereiro, who was speaking at one of the “workshop of solutions” entitled “NTG - a sustainable tool for tackling climate change”, organized by the Forum for the Future of Agriculture (FFA), there are three types of public when it comes to perceptions of NTG.

Part of society “associates these technologies with a greater impact on diversity and ecosystems, and reacts almost emotionally to the application of NTGs,” says February. Then, “there is a public that has difficulty understanding them and associates them with the loss of the traditional component of their production.” There is also, in his opinion, another public who, once they have been enlightened about the new plant breeding techniques, “tend to understand that they are nothing more than a natural process in which we are adjusting the crops we eat to the needs we have as a global society”.

The session was moderated by Cristina Nobre Soares and shared with the member of the European Parliament Álvaro Amaro, agronomist Manuel Chaveiro Soares, Rui Barreiras, from Nature Association Portugal/ WWF and keynote speaker Andreas Weber, director of the Plant Biochemistry Institute of[RF1]  Heinrich Heine University in Germany.

Pedro Fevereiro was convinced that “we will be able to develop new technologies, based on the knowledge that is being accumulated, which will enable us to respond more efficiently to the challenges that lie ahead” - such as feeding the population and ensuring that production can withstand the climate impacts that are already present in Mediterranean territories.

Watch the debate in full.